Chemyonucleolysis vs Microdiscectomy. Prospective Controlled Study with 18 Months
This prospective control study with 18 months follow-up was designed to disclose the differences in outcome between intradiscal ozone chemonucleolysis and microdiscectomy in patients with non-contained lumbar disc herniations. Forty-five patients were enrolled on the basis of precise inclusion and exclusion criteria and divided into two treatment groups selected by the patients themselves. The patients were followed by Visual Analogic Scale (VAS), Roland-Morris Disability Questionaire (RMDQ) and Overall Patient Rating Scale (OPRS). Disc herniation volume morphology was evaluated for five months by control MRI scanning. Twenty-seven patients (90%) in the chemonucleolysis group showed a statistically significant improvement in pain (P<0.001, Wilcoxon test) and function (P<0.001, Wilcoxon test) and the same was true for 14 patients (93.3%) in the microdiscectomy group. The mean satisfaction with the treatment on OPSR was 79.3% for the chemonucleolysis group and 82.1% for the microdiscectomy group. There were no major complications related to procedures. This study indicates that patients from both groups achieved a statistically significant improvement in pain and disability at 18 months follow-up and that there is no statistically significant difference in results between the two treatments.