The Use of Hydrogen Peroxide as a Medical Drug
V. Bocci, Aldinucci, L. Bianchi

Summary

Since 1993, a diluted solution of hydrogen peroxide (H2O2) has been administered intravenously in many ischaemic and neoplastic patients in the USA and Canada as a bio-oxidative therapy. However, to date no biochemical study has defined the behaviour and fate of H2O2 diluted in either human blood or a 5% glucose solution. Our study aimed to define the stability of H2O2 in vitro and in vivo and to compare the generation and stability of reactive oxygen species (ROS) and lipid oxidation products (LOPs) when blood is treated with either ozone or H2O2. In addition, we evaluated the therapeutic effect of the gluco-peroxide solution in age-related macular degeneration (ARMD) patients with encouraging results. There is a general consensus that H2O2 is one of the most important physiological messengers and because it could activate multiple cell targets, H2O2 could become a useful medical drug particularly in countries with scant medical resources.

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