Ozone
Treatment Does Not Induce Toxicity
in Human NIH3T3 Fibroblast Cells
D.
Amendola, B. Bucci, E.
Brunetti, M. Martinelli
SUMMARY -
Ozone
(O2-O3)
has
recently
been
subjected
to
criticism
and
emphasis
in
relation
to
clinical
efficacy
and
toxicity.
It
is
well-established
that
ozone
is
one
of
the
most
potent
oxidants
but
its
toxicity
is
due
to
the
cumulative
ozone
dose
that,
day
by
day,
elicits
the
formation
of
noxious
products.
This
fact
has
established
the
dogma
that
ozone
is
always
toxic
and
its
medical
application
should
be
proscribed.
However,
ozone
therapy
is
becoming
very
useful
both
on
its
own
or
applied
in
combination
with
orthodox
medicine
in
a
broad
range
of
pathologies,
so
it
is
important
to
clarify
this
controversial
issue.
In
order
to
understand
the
problem
of
the
toxicity
induced
by
ozone,
the
aim
of
the
present
study
was
to
evaluate
whether
O2-O3
treatment
could
have
any
toxic
effect
on
the
human
NIH3T3
fibroblast
cell
line.
We
found
that
O2-O3
did
not
induce
toxicity
by
using
the
appropriate
dose
in
contrast
with
the
established
dogma
that
ozone
is
always
toxic
and
its
medical
application
should
be
proscribed.