Topical
Ozonated Autohaemotherapy for
the Treatment of Skin Lesions.
Proposal of a New Method: Concept,
Technique and Initial Clinical
Results
E. Borrelli, M.L. Iabichella,
G. Mosti, V. Bocci
SUMMARY - Chronic skin lesions represent a major socio-economic problem and, in spite of several recent approaches with improved dressings, the healing process remains slow and painful. Previous studies based on a brief and moderate ozonation of human platelets showed a striking release of growth factors together with an effective and mild disinfectant activity. We propose a new method consisting in the controlled ozonation of a small volume of the patient’s blood with its immediate application on skin ulcers of considerable size in both chronic limb arterial ischaemia and venous stasis. The ozonated blood, kept in situ for one day and subsequently renewed at least twice, leads to such a marked improvement as to allow rapid successful implantation of a skin graft. Besides describing the technical details, we report clinical data obtained in patients with ulcers undergoing venous stasis and arterial ischaemia. This new experimental method has been compared with conventional dressings. The reasons explaining the rapid improvements are discussed.